Milestones in Huntington disease
Identifieur interne : 001564 ( Main/Exploration ); précédent : 001563; suivant : 001565Milestones in Huntington disease
Auteurs : Ira Shoulson [États-Unis] ; Anne B. Young [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-05.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Biomedical Research, Brain (pathology), Genetic Testing, History, 19th Century, History, 20th Century, History, 21st Century, Humans, Huntington Disease (epidemiology), Huntington Disease (genetics), Huntington Disease (history), Huntington Disease (therapy), Huntington disease, Nervous system diseases, Treatment, experimental therapeutics, review.
- MESH :
- epidemiology : Huntington Disease.
- genetics : Huntington Disease.
- history : Huntington Disease.
- pathology : Brain.
- therapy : Huntington Disease.
- Animals, Biomedical Research, Genetic Testing, History, 19th Century, History, 20th Century, History, 21st Century, Humans.
Abstract
There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold. © 2011 Movement Disorder Society
Url:
DOI: 10.1002/mds.23685
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">There have been extraordinary advances in our knowledge of the underlying gene, the protein it encodes, various models of disease, and potential targets for effective therapies for Huntington disease. Huntington disease research has increased exponentially in the past 25 years, and we now understand many of the molecular mechanisms underlying the disease. Still, more work needs to be done before we have a full understanding of the pathophysiology of the disease. Clinical research on biomarkers and clinical trials on potential neuroprotective agents are underway. Here we review our progress in these areas over the last 25 years and speculate on what the next 25 years may hold. © 2011 Movement Disorder Society</div>
</front>
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